Understanding the evolution of mammals and their gut microbiota: an alternative way to discover our beneficial microbes

12:00pm-1:00pm, Nov 8, 2017

Room 3402AB, Djavad Mowafaghian Centre for Brain Health
Series: 
Microbiome Seminar Series
Presenter: 
Dr. Florent Mazel

Abstract

Whether mammal-microbiome interactions are persistent and specific over evolutionary time is controversial. Here, we show that host phylogeny and major dietary shifts have affected the distribution of different gut bacterial lineages, and did so on vastly different bacterial phylogenetic resolutions. Diet mostly influences the acquisition of ancient and large microbial lineages. Conversely, correlation with host phylogeny is mostly seen among more recently-diverged bacterial lineages, consistent with processes operating at similar timescales to host evolution. Considering microbiomes at appropriate phylogenetic scales allows us to model their evolution along the mammalian tree, and to infer ancient diets from the predicted microbiomes of mammalian ancestors. Phylogenetic analyses support co-speciation as playing a significant role in the evolution of mammalian gut microbiome compositions. Highly co-speciating bacterial genera are also associated with immune diseases in humans, laying a path for future studies that probe these co-speciating bacteria for signs of co-evolution.

Events

4:00pm-6:00pm, May 12, 2018

Past Events

9:00am-3:00pm, Apr 14, 2018

Lunch will be provided (gluten-free and non-gluten-free options).

7:00pm-9:30pm, Apr 11, 2018

Professor Vesna Sossi will examine how positron emission tomography (PET) imaging has contributed to better understanding of the brain f

12:00pm-1:30pm, Mar 15, 2018

Join host Dr. Tim Inglis and visiting speaker Dr. Andy Murray for a special talk. 

Title: The vestibular system as a gateway to motor circuits

5:30pm-7:30pm, Mar 13, 2018

Medical Aid in Dying in Canada – Where are we and where are we going?

1:00pm-7:30pm, Nov 25, 2017

Join us in celebration as we commemorate 20 years of neuroscience research and brain health discovery at the University of British Columbia.

Oct 31, 2017

The UBC Department of Medicine invites its faculty members, students, and staff to the upcoming 2017 Medicine Research Expo, brought to you by our Department of Medicine Research Office and UBC Exp

12:00pm-1:00pm, Sep 18, 2017

Clinic staff at the Djavad Mowafaghian Centre for Brain Health are excited to be able to bring a Chronic Condition Self-Management Program to the Centre for Brain Health.

7:30pm-9:30pm, Jun 27, 2017

12:30pm-5:30pm, Jun 1, 2017

Join academic researchers and clinicians at the Annual Meeting of the BMBF-ANR-CIHR Consortium on Epigenomics of Parkinson's Disease.